Long-lasting bradypnea induced by repeated social defeat.
Identifieur interne : 001B83 ( Main/Exploration ); précédent : 001B82; suivant : 001B84Long-lasting bradypnea induced by repeated social defeat.
Auteurs : Charly Brouillard [France] ; Pascal Carrive [Australie] ; Françoise Camus [France] ; Jean-Jacques Bénoliel [France] ; Thomas Similowski ; Caroline Sévoz-Couche [France]Source :
- American journal of physiology. Regulatory, integrative and comparative physiology [ 1522-1490 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
- physiopathologie : Anxiété, Hypoventilation.
- Animaux, Comportement animal, Comportement social, Fréquence respiratoire, Mâle, Rat Sprague-Dawley, Rats, Stress psychologique.
English descriptors
- KwdEn :
- MESH :
- physiopathology : Anxiety, Hypoventilation.
- Animals, Behavior, Animal, Male, Rats, Rats, Sprague-Dawley, Respiratory Rate, Social Behavior, Stress, Psychological.
Abstract
Repeated social defeat in the rat induces long-lasting cardiovascular changes associated with anxiety. In this study, we investigated the effects of repeated social defeat on breathing. Respiratory rate was extracted from the respiratory sinus arrhythmia (RSA) peak frequency of the ECG in rats subjected to social defeat for 4 consecutive days. Respiratory rate was recorded under anesthesia 6 days (D+10) or 26 days (D+30) after social defeat. At D+10, defeated (D) rats spent less time in the open arms of the elevated plus maze test, had heavier adrenal glands, and displayed bradypnea, unlike nondefeated animals. At D+30, all signs of anxiety had disappeared. However, one-half of the rats still displayed bradypnea (DL rats, for low respiratory rate indicated by a lower RSA frequency), whereas those with higher respiratory rate (DH rats) had recovered. Acute blockade of the dorsomedial hypothalamus (DMH) or nucleus tractus solitarii (NTS) 5-HT3 receptors reversed bradypnea in all D rats at D+10 and in DL rats at D+30. Respiratory rate was also recorded in conscious animals implanted with radiotelemetric ECG probes. DH rats recovered between D+10 and D+18, whereas DL rats remained bradypneic until D+30. In conclusion, social stress induces sustained chronic bradypnea mediated by DMH neurons and NTS 5-HT3 receptors. These changes are associated with an anxiety-like state that persists until D+10, followed by recovery. However, bradypnea may persist in one-half of the population up until D+30, despite apparent recovery of the anxiety-like state.
DOI: 10.1152/ajpregu.00021.2016
PubMed: 27225946
Affiliations:
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Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière, Charles Foix, Service de Pneumologie et Réanimation Médicale, Paris, France; and.</nlm:affiliation><wicri:noCountry code="subField">France; and</wicri:noCountry></affiliation></author><author><name sortKey="Sevoz Couche, Caroline" sort="Sevoz Couche, Caroline" uniqKey="Sevoz Couche C" first="Caroline" last="Sévoz-Couche">Caroline Sévoz-Couche</name><affiliation wicri:level="3"><nlm:affiliation>Centre de Recherche de l'Institut du Cerveau et de la Moelle Epinière, Institut National de la Santé et de la Recherche Médicale, UMR-S 975, Centre National de la Recherche Scientifique, UMR 7225, Faculté de Médecine University Pierre and Marie Curie, Site Pitié-Salpêtrière, Paris, France; Sorbonne Universités, University Pierre and Marie Curie University Paris 06, Institut National de la Santé et de la Recherche Médicale, UMRS1158, Neurophysiologie Respiratoire Expérimentale et Clinique, Paris, France; caroline.sevoz-couche@upmc.fr.</nlm:affiliation><country wicri:rule="url">France</country><wicri:regionArea>Centre de Recherche de l'Institut du Cerveau et de la Moelle Epinière, Institut National de la Santé et de la Recherche Médicale, UMR-S 975, Centre National de la Recherche Scientifique, UMR 7225, Faculté de Médecine University Pierre and Marie Curie, Site Pitié-Salpêtrière, Paris, France; Sorbonne Universités, University Pierre and Marie Curie University Paris 06, Institut National de la Santé et de la Recherche Médicale, UMRS1158, Neurophysiologie Respiratoire Expérimentale et Clinique, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27225946</idno><idno type="pmid">27225946</idno><idno type="doi">10.1152/ajpregu.00021.2016</idno><idno type="wicri:Area/PubMed/Corpus">001A54</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001A54</idno><idno type="wicri:Area/PubMed/Curation">001A30</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001A30</idno><idno type="wicri:Area/PubMed/Checkpoint">001A30</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001A30</idno><idno type="wicri:Area/Ncbi/Merge">003599</idno><idno type="wicri:Area/Ncbi/Curation">003599</idno><idno type="wicri:Area/Ncbi/Checkpoint">003599</idno><idno type="wicri:Area/Main/Merge">001B80</idno><idno type="wicri:Area/Main/Curation">001B83</idno><idno type="wicri:Area/Main/Exploration">001B83</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Long-lasting bradypnea induced by repeated social defeat.</title><author><name sortKey="Brouillard, Charly" sort="Brouillard, Charly" uniqKey="Brouillard C" first="Charly" last="Brouillard">Charly Brouillard</name><affiliation wicri:level="3"><nlm:affiliation>Centre de Recherche de l'Institut du Cerveau et de la Moelle Epinière, Institut National de la Santé et de la Recherche Médicale, UMR-S 975, Centre National de la Recherche Scientifique, UMR 7225, Faculté de Médecine University Pierre and Marie Curie, Site Pitié-Salpêtrière, Paris, France; Sorbonne Universités, University Pierre and Marie Curie University Paris 06, Institut National de la Santé et de la Recherche Médicale, UMRS1158, Neurophysiologie Respiratoire Expérimentale et Clinique, Paris, France;</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre de Recherche de l'Institut du Cerveau et de la Moelle Epinière, Institut National de la Santé et de la Recherche Médicale, UMR-S 975, Centre National de la Recherche Scientifique, UMR 7225, Faculté de Médecine University Pierre and Marie Curie, Site Pitié-Salpêtrière, Paris, France; Sorbonne Universités, University Pierre and Marie Curie University Paris 06, Institut National de la Santé et de la Recherche Médicale, UMRS1158, Neurophysiologie Respiratoire Expérimentale et Clinique, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Carrive, Pascal" sort="Carrive, Pascal" uniqKey="Carrive P" first="Pascal" last="Carrive">Pascal Carrive</name><affiliation wicri:level="1"><nlm:affiliation>Blood Pressure, Brain and Behavior Laboratory, School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Blood Pressure, Brain and Behavior Laboratory, School of Medical Sciences, University of New South Wales, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Camus, Francoise" sort="Camus, Francoise" uniqKey="Camus F" first="Françoise" last="Camus">Françoise Camus</name><affiliation wicri:level="3"><nlm:affiliation>Centre de Recherche de l'Institut du Cerveau et de la Moelle Epinière, Institut National de la Santé et de la Recherche Médicale, UMR-S 975, Centre National de la Recherche Scientifique, UMR 7225, Faculté de Médecine University Pierre and Marie Curie, Site Pitié-Salpêtrière, Paris, France;</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre de Recherche de l'Institut du Cerveau et de la Moelle Epinière, Institut National de la Santé et de la Recherche Médicale, UMR-S 975, Centre National de la Recherche Scientifique, UMR 7225, Faculté de Médecine University Pierre and Marie Curie, Site Pitié-Salpêtrière, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Benoliel, Jean Jacques" sort="Benoliel, Jean Jacques" uniqKey="Benoliel J" first="Jean-Jacques" last="Bénoliel">Jean-Jacques Bénoliel</name><affiliation wicri:level="3"><nlm:affiliation>Centre de Recherche de l'Institut du Cerveau et de la Moelle Epinière, Institut National de la Santé et de la Recherche Médicale, UMR-S 975, Centre National de la Recherche Scientifique, UMR 7225, Faculté de Médecine University Pierre and Marie Curie, Site Pitié-Salpêtrière, Paris, France;</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre de Recherche de l'Institut du Cerveau et de la Moelle Epinière, Institut National de la Santé et de la Recherche Médicale, UMR-S 975, Centre National de la Recherche Scientifique, UMR 7225, Faculté de Médecine University Pierre and Marie Curie, Site Pitié-Salpêtrière, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Similowski, Thomas" sort="Similowski, Thomas" uniqKey="Similowski T" first="Thomas" last="Similowski">Thomas Similowski</name><affiliation><nlm:affiliation>Sorbonne Universités, University Pierre and Marie Curie University Paris 06, Institut National de la Santé et de la Recherche Médicale, UMRS1158, Neurophysiologie Respiratoire Expérimentale et Clinique, Paris, France; Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière, Charles Foix, Service de Pneumologie et Réanimation Médicale, Paris, France; and.</nlm:affiliation><wicri:noCountry code="subField">France; and</wicri:noCountry></affiliation></author><author><name sortKey="Sevoz Couche, Caroline" sort="Sevoz Couche, Caroline" uniqKey="Sevoz Couche C" first="Caroline" last="Sévoz-Couche">Caroline Sévoz-Couche</name><affiliation wicri:level="3"><nlm:affiliation>Centre de Recherche de l'Institut du Cerveau et de la Moelle Epinière, Institut National de la Santé et de la Recherche Médicale, UMR-S 975, Centre National de la Recherche Scientifique, UMR 7225, Faculté de Médecine University Pierre and Marie Curie, Site Pitié-Salpêtrière, Paris, France; Sorbonne Universités, University Pierre and Marie Curie University Paris 06, Institut National de la Santé et de la Recherche Médicale, UMRS1158, Neurophysiologie Respiratoire Expérimentale et Clinique, Paris, France; caroline.sevoz-couche@upmc.fr.</nlm:affiliation><country wicri:rule="url">France</country><wicri:regionArea>Centre de Recherche de l'Institut du Cerveau et de la Moelle Epinière, Institut National de la Santé et de la Recherche Médicale, UMR-S 975, Centre National de la Recherche Scientifique, UMR 7225, Faculté de Médecine University Pierre and Marie Curie, Site Pitié-Salpêtrière, Paris, France; Sorbonne Universités, University Pierre and Marie Curie University Paris 06, Institut National de la Santé et de la Recherche Médicale, UMRS1158, Neurophysiologie Respiratoire Expérimentale et Clinique, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j">American journal of physiology. Regulatory, integrative and comparative physiology</title><idno type="eISSN">1522-1490</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Anxiety (physiopathology)</term><term>Behavior, Animal</term><term>Hypoventilation (physiopathology)</term><term>Male</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Respiratory Rate</term><term>Social Behavior</term><term>Stress, Psychological</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anxiété (physiopathologie)</term><term>Comportement animal</term><term>Comportement social</term><term>Fréquence respiratoire</term><term>Hypoventilation (physiopathologie)</term><term>Mâle</term><term>Rat Sprague-Dawley</term><term>Rats</term><term>Stress psychologique</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Anxiété</term><term>Hypoventilation</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Anxiety</term><term>Hypoventilation</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Behavior, Animal</term><term>Male</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Respiratory Rate</term><term>Social Behavior</term><term>Stress, Psychological</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Comportement animal</term><term>Comportement social</term><term>Fréquence respiratoire</term><term>Mâle</term><term>Rat Sprague-Dawley</term><term>Rats</term><term>Stress psychologique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Repeated social defeat in the rat induces long-lasting cardiovascular changes associated with anxiety. In this study, we investigated the effects of repeated social defeat on breathing. Respiratory rate was extracted from the respiratory sinus arrhythmia (RSA) peak frequency of the ECG in rats subjected to social defeat for 4 consecutive days. Respiratory rate was recorded under anesthesia 6 days (D+10) or 26 days (D+30) after social defeat. At D+10, defeated (D) rats spent less time in the open arms of the elevated plus maze test, had heavier adrenal glands, and displayed bradypnea, unlike nondefeated animals. At D+30, all signs of anxiety had disappeared. However, one-half of the rats still displayed bradypnea (DL rats, for low respiratory rate indicated by a lower RSA frequency), whereas those with higher respiratory rate (DH rats) had recovered. Acute blockade of the dorsomedial hypothalamus (DMH) or nucleus tractus solitarii (NTS) 5-HT3 receptors reversed bradypnea in all D rats at D+10 and in DL rats at D+30. Respiratory rate was also recorded in conscious animals implanted with radiotelemetric ECG probes. DH rats recovered between D+10 and D+18, whereas DL rats remained bradypneic until D+30. In conclusion, social stress induces sustained chronic bradypnea mediated by DMH neurons and NTS 5-HT3 receptors. These changes are associated with an anxiety-like state that persists until D+10, followed by recovery. However, bradypnea may persist in one-half of the population up until D+30, despite apparent recovery of the anxiety-like state.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><noCountry><name sortKey="Similowski, Thomas" sort="Similowski, Thomas" uniqKey="Similowski T" first="Thomas" last="Similowski">Thomas Similowski</name></noCountry><country name="France"><region name="Île-de-France"><name sortKey="Brouillard, Charly" sort="Brouillard, Charly" uniqKey="Brouillard C" first="Charly" last="Brouillard">Charly Brouillard</name></region><name sortKey="Benoliel, Jean Jacques" sort="Benoliel, Jean Jacques" uniqKey="Benoliel J" first="Jean-Jacques" last="Bénoliel">Jean-Jacques Bénoliel</name><name sortKey="Camus, Francoise" sort="Camus, Francoise" uniqKey="Camus F" first="Françoise" last="Camus">Françoise Camus</name><name sortKey="Sevoz Couche, Caroline" sort="Sevoz Couche, Caroline" uniqKey="Sevoz Couche C" first="Caroline" last="Sévoz-Couche">Caroline Sévoz-Couche</name></country><country name="Australie"><noRegion><name sortKey="Carrive, Pascal" sort="Carrive, Pascal" uniqKey="Carrive P" first="Pascal" last="Carrive">Pascal Carrive</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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